Cardiac Hill sets the tone early
The 50K drops off the rim toward the river early, then climbs back up Cardiac Hill, the first of the four named climbs, while your legs are still fresh. And that is exactly the trap. A hard climb this early feels easy to attack, and attacking it is how runners get to the back half climbs already cooked. Hike the steep pitches with purpose and save your running legs for the runnable, rolling sections.
After the opening loop you come back through the start area aid near Gate 142 to refuel, and then you head out toward No Hands Bridge and the bigger middle climbs. Treat this early part as setup. It is not a place to bank time.