One bad downhill makes the next one easy
After a single session of downhill running or heavy eccentric work, you get less soreness, a smaller drop in strength, and faster recovery the next time you do it. That is the repeated bout effect, and it is real and well documented. It shows up after just one exposure, and the protection sticks around for a long time, with studies finding meaningful carryover for weeks and in some cases out to around six months without any further eccentric work.
So the strategy writes itself. Do not protect your legs from downhills and then go race a mountain 100K on virgin quads. Give your legs the damage in training, on purpose, in controlled doses, and let them armor up. The first real downhill session of your build will leave you walking down stairs backward. The third or fourth will barely touch you. That difference is the entire reason this works, and it is why a runner who trains descents holds far more of their leg strength deep into a race than one who avoids them.