Altitude is the hidden difficulty
The thing that catches first-timers out here is the altitude. The whole course sits above 6,000 feet, and the climbs push higher into the Holcomb Valley terrain. There is no one monster ascent, but the thin air taxes every grade, and a pace that feels easy at sea level can quietly redline you up here. If you are coming from low elevation, expect your heart rate to sit higher and your climbing pace to feel slower than your training numbers say it should.
So treat the early climbing as effort, not pace. Settle into a breathing rhythm you can hold, power-hike the steep pitches with purpose, and let the runnable PCT come to you. Banking a bunch of time hard on the first climbs at altitude is the classic way to show up at the late miles with nothing left in your legs.