The chain reaction: tired hips, dropped pelvis, leaning trunk
It goes like this. Your glute medius is the muscle that holds your pelvis level every time you land on one leg. When it fatigues it stops doing that job, so the opposite hip drops on each stride. That is the Trendelenburg pattern, and it shows up in fatigued runners over and over in the research. To stay upright you start leaning your trunk toward the planted leg to compensate, which throws your whole stride off and dumps extra load onto your knee and IT band.
None of this feels dramatic in the moment. It feels like you are just getting tired and your stride is shrinking. But a lot of that back-half shuffle is a stability failure, not a fitness one. The fix is to build hips and a core that can hold their shape under fatigue, so the chain never starts. That is the whole point of this kind of training: not a six-pack, but a stride that does not collapse at mile 40.