What the research actually says
Here is a fair gut-check on the "two days are not the same as one" worry, because they are not identical, and that is fine. One study took the same 169 km and had runners do it either in a single stage or split across four days (about 40 km a day), then measured the damage. The single-stage run caused more central fatigue right after, the nervous-system kind where your brain stops fully driving the muscle. The multi-day version left more lasting muscle-contractile fatigue that took longer to clear. So a B2B is not a perfect copy of a one-shot ultra. But for training, that tired-legs, contractile-fatigue stimulus is exactly the adaptation you are chasing, and you get it without one giant run trying to break you in a single afternoon.
And the fitness math is the honest part of the argument. Logging a pile of 6 to 8 hour single runs does not give you meaningfully more fitness than well-managed 4 to 5 hour runs or back-to-backs, it just hands you more injury risk, more fatigue, and a longer recovery. So you are not giving anything up by skipping the monster run. You are keeping the upside and dropping the part that gets you hurt.