No single monster climb, just relentless rolling
The thing to understand about this place is that the vert does not come from one big climb you can see on the map and brace for. It comes from a long string of forested ups and downs that just keep coming, all day. On the 50 mile you start climbing toward Kings Mountain early, then trade one drainage for the next through Elk Creek, Idiot Creek, Storey Burn, and University Falls before the run-in to Reehers Camp. None of it is brutally steep, but it adds up, and the runners who blow up here are the ones who treated the early rolling miles like they were free.
Be patient with the climbs and hike the steep, rooty pitches efficiently instead of forcing a run. If you keep your effort even across the first half you reach the back end with legs left, and if you hammer the early descents because the trail is soft and fast you will feel it in your quads with twenty miles still to go.