The opening climb: long, steady, and easy to overcook
The first 9.7 miles or so are one long, gradual grind, roughly 2,300 feet of gain, up through ponderosa forest and the regrowth from the 2012 Pole Creek burn to the first aid station near the Wilderness edge. It almost never gets truly steep, and that is exactly the trap. The grade is gentle enough that you can run most of it, so the temptation is to hammer the climb because it feels totally doable in the cool morning air.
Do not. This is where the race is quietly won or lost. Settle into a steady, conversational effort, hike the few stiffer pitches if it keeps your heart rate down, and arrive at the top with your legs intact. The reward is real: as you crest toward the Wilderness boundary the Three Sisters open up dead ahead, and you still have plenty in the tank to use them.