The climbs and the altitude: pace them or pay later
Standhope is a climbing race first. The 100 spends the day going up and over high passes and ridgelines, paying out more than 23,000 feet of gain, and you do a lot of it above 9,000 feet with high points near 11,000. That altitude makes every grade feel harder than the same hill at home, so this is not a place to muscle the climbs. Hike the steep pitches with purpose, keep your effort honest, and get to the top with something left. Burn matches early up high and the altitude collects the debt with interest on the back half.
If you live at low elevation, the thin air is the part people most underestimate here. Pace the early climbs by breathing and feel, not by your sea-level splits, and give yourself permission to go easy. There is a very long way to go.