The altitude is the real climb
Most course guides start with the biggest hill. Here the headline is that there is barely any low ground at all. You start at altitude and you stay there, rolling and climbing across exposed high country for the entire race, which means the thin air taxes every single mile, not just the steep ones. A grade that you would jog without a thought near sea level becomes a hike up here, and your top-end pace on the runnable roads is capped no matter how fit you are.
So the way to think about Sheep Mountain is not "save it for the big climb." It is "respect the altitude from the first step." The runners who blow up are usually the ones who treated the early miles like a normal 50 and spent energy they could not get back in air this thin.