The sand: the difficulty nobody warns you about
The washes are the real story here. Long stretches of this course run through soft, sandy desert wash, and that sand quietly eats your pace and your legs in a way the elevation profile never shows. On the 50K there is a stretch between roughly miles 7 and 15 that runners have nicknamed Dream Killer, because that is where a hoped-for PR tends to die. It is not steep. It is just relentless, soft, and exposed.
Do not fight the sand. Shorten your stride, keep your effort even, walk the softest patches if you have to, and let your watch pace look ugly without panicking. People who try to force road pace through the washes burn matches they need later. The ones who settle into a patient desert shuffle come out the other side with legs to spare.