The stairs and the climb to Cardiac
Within a few hundred yards of the gun you are climbing three flights of stairs that rise as tall as a 50-story building, 686 steps in the first three flights alone. They are a shock cold off the start line, and you hit them four times across the day. Past the stairs the trail heads up through an old horse ranch to Windy Gap, then plunges down into Muir Woods across Redwood Creek and starts the long grind up through trees and grassland over sections named Dynamite, the Hogsback, the Rainforest, and finally Cardiac.
The climb to the top of Cardiac is the signature effort of each crossing, and the temptation is to power up it early when the legs feel fresh. Do not. You have got this climb in front of you four times, so hike the steep pitches efficiently and keep your effort honest. The runners who blow up here on lap one or two are walking it by lap four.