The navigation: an unmarked course you have to know
This is the thing that makes Plain different from almost every other hundred. There is no marked course and no flagging, so you are responsible for finding your own way the entire time. Finishers study the course directions, carry maps and a loaded GPS track, and know the junctions before they ever toe the line. People who have finished before still take wrong turns out here, usually deep in the night when they are tired and the trail forks in the dark.
Treat navigation as a trained skill, not a hope. Build the track on your watch, learn the key decision points, and pre-run sections if you can get out to the forest beforehand. A blown turn at Plain is not just bonus miles. It is the water and the food you budgeted for one leg getting spent on a leg you did not plan for, and that is how self-supported days unravel.