Down into the canyon: free speed you can overspend
The early miles drop you off the rim and down toward the river, and the descending feels great, which is exactly the trap. This is famous Western States ground, rocky and rolling, and it is easy to let the early downhill turn into hammering because your legs feel fresh and the grade is doing the work for you. Do not. Every foot you drop into the canyon is a foot you have to earn back later, and the quads you trash on the way down are the quads you will beg for on the climb to the Overlook.
Keep the early descending controlled and quick-footed rather than reckless. Save the legs. The runners who float the downhills smoothly and patiently are the ones still moving well when the canyon heats up.