Loop one: bank patience, not time
The loop opens with a long pull away from Kentucky Camp toward the high ground, and the first aid is several uphill miles in, so you settle into climbing right out of the gate. This early stretch is where people make their big mistake. It feels easy, the legs are fresh, the desert morning is cool, and you run it harder than you should. Do not. The loop has a lot of rocky, rutted footing that quietly taxes your feet and ankles, and what you spend here you do not get back on loop two.
Run loop one well within yourself and arrive back at Kentucky Camp (mile 25) feeling like you are barely working. The first-loop cutoff is 1:00 PM, and most prepared runners clear that with plenty of room, so there is no reason to chase time early. The goal of the first loop is to set up the second one.