The early climbs: 7 Utes and North Diamond
The day opens with the 7 Utes climb, then North Diamond, and these early passes are where patient runners separate from the people who will be hurting later. It is tempting to climb hard while your legs are fresh and the sun is low, but you are already above 10,000 feet, and burning matches up here at the start is the single most common Never Summer mistake. Hike the steep parts, keep your effort honest, and save your enthusiasm for the second half.
Up top you get the Medicine Bow ridge between the Diamond and Montgomery aid, traversing around 11,000 feet with the big views and the full exposure that comes with them. The footing changes constantly, from runnable to rocky and slow, so this is as much about staying smooth and paying attention as it is about fitness.