The desert and the slickrock: exposure and footing
Big chunks of this loop run through open desert and slickrock with almost no shade. That means long, sun-exposed, dry stretches where the heat and the lack of cover do real damage if you are careless with water and your core temperature. The footing alone is a whole skill: soft sand that saps your legs, hardpack, and sharp red slickrock that is fast when you can read it and ankle-rolling when you cannot.
This is where a steady, patient early pace pays off the most. It is easy to feel great on fresh legs in the cool morning and push the runnable desert, but you have days ahead. Protect your feet from the sand and grit from the very first miles, because foot problems on a 240 do not heal, they just compound.