The vert comes in waves, not one big climb
This is the thing to understand about Lookout. The 6,600 feet is not one monster ascent you can brace for. It comes in rollers, repeated climbs and moderate descents stacked across 50 miles, with the bigger drop down toward Lula Lake and the grind back out of that basin. Each climb on its own feels fine. That is the trap. You run the rollers a touch too hard for the first 30 miles because none of them hurt, and then the cumulative load shows up all at once in the back half.
Run the early rollers easier than feels necessary. Power-hike the steeper pitches from the gun, even when your legs are begging to run them, and bank that energy for the climb back up to the finish. The people who race this well are not the ones who attack the first half. They are the ones who still have legs at mile 40.