The dark start and the first big climbs
You start at 3 AM in the dark, which sounds dramatic but actually works in your favor: the first climbs are cool and you are fresh. Resist the urge to hammer them. The early grade feels easy because you are rested and caffeinated and it is cold, and that is exactly the trap. Hike the steep pitches with purpose, keep your heart rate boringly low, and treat the first few hours as money in the bank, not a chance to bank time.
These opening miles climb toward the high country and the long pull to Lightning Ridge up around mile 19 or 20. It is a grind of a climb followed by a serious, steep descent off the ridge that drops thousands of feet in just a few miles. That descent is the first place the day starts billing your quads. Go down it controlled, light feet, short strides, because you have a long way to go.