The altitude: the thing that actually makes this hard
This is the part flatland runners get wrong. The course sits at real elevation, starting in the low 6,000s of feet and climbing well above treeline, and that thin air taxes you the whole day whether you notice it early or not. Efforts that feel like a jog at sea level turn into labored breathing up here, and your usual pace just will not be there. If you live down low, plan to run the climbs a notch easier than your legs want, because the altitude is the real cutoff, not the grade.
If you can get up to elevation for a few days before the race, or you are coming from somewhere high already, you will feel the difference. If you cannot, do not panic, just be honest with your effort and patient with your splits.