The midnight start and the long dark out-and-back
You line up at midnight under a full moon, the marathon and 51K go first right around 12:01 AM, and you head out the ET Highway into real darkness. There are no streetlights out here. Your headlamp and the moon are it, and the road just unrolls in front of you toward a turnaround and back. The 51K runs the longest version of that out-and-back, splitting off from the marathon late before it loops home, so you spend the most time alone on the road.
The trap on a course like this is the monotony. Smooth pavement and a straight dark highway make it very easy to drift, either pushing too hard because nothing hurts yet, or zoning out and letting your effort sag without noticing. Break the night into chunks between the turnarounds and the aid, and run each chunk on purpose. Don’t let the road hypnotize you.