The loop: your biggest weapon and your biggest trap
The loop is the whole story here. You pass the main aid station roughly every mile, which means you are never far from your drop bag, your crew, your spare bottle, or a chair. That is a massive advantage. You can carry almost nothing, top off fluid constantly, change socks the second something feels off, and break a hundred miles into chunks you can actually hold in your head.
The flip side is mental. The same stretch of path on repeat will start to grind on you somewhere in the back half, usually right when the novelty wears off and the fatigue shows up. The runners who do well here stop thinking about the full distance and start running lap to lap, gel to gel, aid stop to aid stop. Give your brain a tiny target and keep feeding it one.