The early miles and the blast zone: bank patience, not time
You start at Marble Mountain Sno-Park on the south side of Mount St. Helens, and the first day takes you around the mountain and out into the otherworldly volcanic terrain it left behind in 1980. Lava fields, pumice, blowdown, open exposed slopes with huge views. It is stunning, and it is a trap. Everybody feels fresh and the scenery pulls you along, so the single biggest mistake here is running the early sections too hard because your legs feel great. You cannot win Bigfoot in the first 50 miles, but you can absolutely lose it. Hike the climbs, keep the effort easy, and treat the whole first day as a warm-up.
The footing out here is rough and the exposure is real, so this is also where you settle into the habits that have to last for days: eat on a schedule, drink to the heat, take care of your feet early. The runners who fix a hot spot at mile 30 instead of mile 80 are the ones still moving on day four.