The high country: get your climbing done early
You start cold and high, then drop into Cuyamaca Rancho State Park and do most of the day’s real climbing in the first half, including the pull up toward Stonewall Peak and the wooded trails around the lake. This is the part to run with discipline. The course gives back so much elevation later that it is tempting to hammer the climbs early because you know a downhill payday is coming, but that is exactly how you arrive at the long descent with nothing in your quads.
Keep the early climbs to a steady, repeatable effort and hike the steep pitches without ego. The high country footing is mostly friendly mountain single-track and fire road, but you are up at real elevation in December, so it can be genuinely cold here even when the desert finish will be warm. Start with enough layers to climb comfortably and plan where you will shed them.